Increased spinal cholecystokinin activity after systemic resiniferatoxin: electrophysiological and in situ hybridization studies.

Authors

Christian Broberger
Tunde Farkas MD, Lehigh Valley Health NetworkFollow
Arpad Szallasi
Jan M Lundberg
Tomas Hökfelt
Zsuzsanna Wiesenfeld-Hallin
Xiao-Jun Xu

Publication/Presentation Date

1-1-2000

Abstract

The present study assessed the effect of a single subcutaneous injection of resiniferatoxin (RTX), an ultrapotent capsaicin analogue, on the activity of spinal cholecystokinin (CCK) systems, by using electrophysiological and in situ hybridization techniques. Subcutaneous RTX at 0.3 mg/kg, but not vehicle, produced marked thermal hypoalgesia in rats on the hot plate and tail flick tests. Partial recovery from hypoalgesia occurred in some (

Volume

84

Issue

1

First Page

21

Last Page

28

ISSN

0304-3959

Published In/Presented At

Broberger, C., Farkas-Szallasi, T., Szallasi, A., Lundberg, J. M., Hökfelt, T., Wiesenfeld-Hallin, Z., & Xu, X. J. (2000). Increased spinal cholecystokinin activity after systemic resiniferatoxin: electrophysiological and in situ hybridization studies. Pain, 84(1), 21–28. https://doi.org/10.1016/S0304-3959(99)00173-6

Disciplines

Medicine and Health Sciences

PubMedID

10601669

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article