Increased spinal cholecystokinin activity after systemic resiniferatoxin: electrophysiological and in situ hybridization studies.
The present study assessed the effect of a single subcutaneous injection of resiniferatoxin (RTX), an ultrapotent capsaicin analogue, on the activity of spinal cholecystokinin (CCK) systems, by using electrophysiological and in situ hybridization techniques. Subcutaneous RTX at 0.3 mg/kg, but not vehicle, produced marked thermal hypoalgesia in rats on the hot plate and tail flick tests. Partial recovery from hypoalgesia occurred in some (
Published In/Presented At
Broberger, C., Farkas-Szallasi, T., Szallasi, A., Lundberg, J. M., Hökfelt, T., Wiesenfeld-Hallin, Z., & Xu, X. J. (2000). Increased spinal cholecystokinin activity after systemic resiniferatoxin: electrophysiological and in situ hybridization studies. Pain, 84(1), 21–28. https://doi.org/10.1016/S0304-3959(99)00173-6
Medicine and Health Sciences
Department of Pathology and Laboratory Medicine