Iron deposits surrounding multiple sclerosis plaques.
Publication/Presentation Date
8-1-1982
Abstract
Autopsy samples from cerebral areas of five brains from patients with multiple sclerosis (MS) and from six control brains were stained with Perls acid ferrocyanide to detect nonheme iron present as hemosiderin. Positive iron reactions were observed only in MS sections surrounding demyelinated plaques. Myelinated white matter near the lesion contained numerous iron-laden ovoid bodied and axons that stained positively for iron. Positive reactions were also found within blood vessels of gray matter near the lesion. A possible source of the iron was extravasated blood.
Volume
106
Issue
8
First Page
397
Last Page
399
ISSN
0003-9985
Published In/Presented At
Craelius, W., Migdal, M. W., Luessenhop, C. P., Sugar, A., & Mihalakis, I. (1982). Iron deposits surrounding multiple sclerosis plaques. Archives of pathology & laboratory medicine, 106(8), 397–399.
Disciplines
Medicine and Health Sciences
PubMedID
6896630
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article