Immunospecificity of nuclear nonhistone protein-DNA complexes in colon adenocarcinoma.
Publication/Presentation Date
8-1-1979
Abstract
Tumor-specific antisera against dehistonized chromatin isolated from transplantable colon adenocarcinoma (from male noninbred Sprague-Dawley rats) were produced. The specificities of these antisera were determined by complement fixation. In the presence of these antisera, only chromatin from colon adenocarcinoma significantly fixed complement, whereas chromatins isolated from normal rat colon epithelia were inactive. Administration of 1,2-dimethylhydrazine to rats produced an early change in the immunospecificity of colon epithelial chromatin similar to that for colon adenocarcinoma. Several lines of experimental evidence indicated that nuclear antigen was not a carcinoembryonic antigen-like substance. Common antigens were also present in human colon adenocarcinomas.
Volume
63
Issue
2
First Page
313
Last Page
317
ISSN
0027-8874
Published In/Presented At
Chiu, J. F., Decha-Umphal, W., Markert, C., & Little, B. W. (1979). Immunospecificity of nuclear nonhistone protein-DNA complexes in colon adenocarcinoma. Journal of the National Cancer Institute, 63(2), 313–317.
Disciplines
Medicine and Health Sciences
PubMedID
88536
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article