Evidence of vascular growth associated with laser treatment of normal canine myocardium.
Publication/Presentation Date
5-1-1998
Abstract
BACKGROUND: Transmyocardial laser revascularization is a new therapy for patients with refractory angina. Although clinical studies suggest that transmyocardial laser revascularization decreases angina and may improve regional blood flow, the underlying mechanisms are not elucidated. We hypothesized that one mechanism may relate to stimulation of vascular growth in laser-treated regions.
METHODS: Transmyocardial laser revascularization channels were made with holmium:yttrium-aluminum garnet or carbon dioxide lasers in eight normal canine hearts; animals were sacrificed 2 to 3 weeks later and examined for vascular density and for evidence of smooth muscle proliferation.
RESULTS: The original channels were infiltrated by granulation tissue with associated vascularity. Vascular growth was stimulated immediately surrounding the channel remnant as evidenced by an increase in the number of vessels (approximately twice that of the control region) and an increase in the number of vascular cells staining positive for markers of cellular proliferation.
CONCLUSIONS: Transmyocardial laser revascularization leads to local vascular growth as early as 2 weeks after treatment. It remains to be determined whether this mechanism contributes to increased regional blood flow or to clinical benefits associated with this novel form of therapy.
Volume
65
Issue
5
First Page
1360
Last Page
1367
ISSN
0003-4975
Published In/Presented At
Kohmoto, T., DeRosa, C. M., Yamamoto, N., Fisher, P. E., Failey, P., Smith, C. R., & Burkhoff, D. (1998). Evidence of vascular growth associated with laser treatment of normal canine myocardium. The Annals of thoracic surgery, 65(5), 1360–1367. https://doi.org/10.1016/s0003-4975(98)00236-7
Disciplines
Medicine and Health Sciences
PubMedID
9594867
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article