Microwave technology for the rapid thawing of frozen blood components.
Based on a continuing need to provide a more rapid response to requests for thawed fresh frozen plasma, the authors evaluated plasma thawing with the use of a microwave oven and compared it with conventional 37 degrees C waterbath thawing methods. Their results indicate that microwave-thawed plasma contains precipitated denatured protein (mainly albumin and fibrinogen) and that there is a significant reduction of coagulation Factors IX, X, XI, and fibrinogen compared with fresh plasma. They also measured levels of di-ethyl hexyl phthalate after microwave thawing and found its rate of accumulation similar to that of the 37 degrees C waterbath. More importantly, fundamental principles of microwave heating preclude uniform temperatures being maintained throughout the thawing of plasma; hence, the denaturation of plasma proteins is expected to occur under even low heating conditions.
Published In/Presented At
Luff, R. D., Kessler, C. M., & Bell, W. R. (1985). Microwave technology for the rapid thawing of frozen blood components. American journal of clinical pathology, 83(1), 59–64. https://doi.org/10.1093/ajcp/83.1.59
Medicine and Health Sciences
Department of Pathology and Laboratory Medicine