Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway.
Publication/Presentation Date
8-1-2018
Abstract
BACKGROUND/AIM: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate that α-santalol treatment targets Wnt/β-catenin pathway to inhibit migration of cultured breast cancer cells.
MATERIALS AND METHODS: Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of a-santalol in breast cancer cells.
RESULTS: Exposure of MDA-MB 231 and MCF-7 cells to α-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells.
CONCLUSION: Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies.
Volume
38
Issue
8
First Page
4475
Last Page
4480
ISSN
1791-7530
Published In/Presented At
Bommareddy, A., Knapp, K., Nemeth, A., Steigerwalt, J., Landis, T., Vanwert, A. L., Gorijavolu, H. P., & Dwivedi, C. (2018). Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway. Anticancer research, 38(8), 4475–4480. https://doi.org/10.21873/anticanres.12750
Disciplines
Pharmacy and Pharmaceutical Sciences
PubMedID
30061212
Department(s)
Department of Pharmacy
Document Type
Article
