Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia.
INTRODUCTION: Traumatic brain injury (TBI) may alter the course of neuropsychiatric symptom (NPS) onset during dementia development. The connection among TBI, NPS, and dementia progression is of increasing interest to researchers and clinicians.
METHODS: Incidence of NPS was examined in participants with normal cognition who progressed to all-cause dementia based on whether TBI history was present (n = 130) or absent (n = 849). Survival analyses were used to examine NPS incidence across 7.6 ± 3.0 years of follow-up.
RESULTS: Participants with TBI history had increased prevalence and incidence of apathy (44.7% vs 29.9%, P = .0062; HR
DISCUSSION: History of TBI is associated with increased risk for and earlier onset of NPS in the trajectory of dementia development.
Published In/Presented At
Bray MJC, Richey LN, Bryant BR, Krieg A, Jahed S, Tobolowsky W, LoBue C, Peters ME. Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia. Alzheimers Dement. 2021 Apr;17(4):686-691. doi: 10.1002/alz.12225. Epub 2021 Jan 19. PMID: 33470043; PMCID: PMC8043985.
Department of Psychiatry