Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways.
This study examined the association between depressive symptoms, as well as depressive symptom dimensions, and three candidate biological pathways linking them to Obstructive sleep apnea (OSA): (1) inflammation; (2) circulating leptin; and (3) intermittent hypoxemia. Participants included 181 obese adults with moderate-to-severe OSA enrolled in the Cardiovascular Consequences of Sleep Apnea (COSA) trial. Depressive symptoms were measured using the Beck Depression Inventory-II (BDI-II). We assessed inflammation using C-reactive protein levels (CRP), circulating leptin by radioimmunoassay using a double antibody/PEG assay, and intermittent hypoxemia by the percentage of sleep time each patient had below 90% oxyhemoglobin saturation. We found no significant associations between BDI-II total or cognitive scores and CRP, leptin, or percentage of sleep time below 90% oxyhemoglobin saturation after controlling for relevant confounding factors. Somatic symptoms, however, were positively associated with percentage of sleep time below 90% saturation (β = 0.202, P = 0.032), but not with CRP or circulating leptin in adjusted models. Another significant predictor of depressive symptoms included sleep efficiency (β
Published In/Presented At
Chirinos, D. A., Gurubhagavatula, I., Broderick, P., Chirinos, J. A., Teff, K., Wadden, T., Maislin, G., Saif, H., Chittams, J., Cassidy, C., Hanlon, A. L., & Pack, A. I. (2017). Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways. Journal of behavioral medicine, 40(6), 955–963. https://doi.org/10.1007/s10865-017-9869-4
Psychiatry | Psychiatry and Psychology
Department of Psychiatry