Bladder Preservation Therapy: A Review of the Literature and Future Directions.
Publication/Presentation Date
10-1-2016
Abstract
Trimodal bladder preservation therapy (ie, transurethral resection followed by chemoradiotherapy) may be an acceptable treatment alternative to radical cystectomy with urinary diversion in the carefully selected patient with muscle invasive bladder cancer. Although no head-to-head randomized controlled trials have been performed, large retrospective cohort reviews and observational data analyses suggest comparable oncologic outcomes in select patients with the additional benefit of maximizing quality of life and maintaining the patient's native bladder. In this review, we discuss the evolution and clinical outcomes of bladder preservation therapy, highlighting its role in the contemporary management of muscle invasive bladder cancer.
Volume
96
First Page
54
Last Page
61
ISSN
1527-9995
Published In/Presented At
Cahn, D. B., Ristau, B. T., Ghiraldi, E. M., Churilla, T. M., Geynisman, D. M., Horwitz, E. M., Uzzo, R. G., & Smaldone, M. C. (2016). Bladder Preservation Therapy: A Review of the Literature and Future Directions. Urology, 96, 54–61. https://doi.org/10.1016/j.urology.2016.05.041
Disciplines
Medicine and Health Sciences | Oncology
PubMedID
27257135
Department(s)
Department of Radiation Oncology
Document Type
Article