Late effects after treatment of twenty children with soft tissue sarcomas of the head and neck. Experience at a single institution with a review of the literature.
Publication/Presentation Date
5-15-1986
Abstract
Twenty children with soft tissue sarcomas of the head and neck, treated at the Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania from 1972 to 1981, were evaluated for the late deleterious effects of treatment. All patients received radiation therapy and combination chemotherapy with vincristine, dactinomycin, and cyclophosphamide; certain patients also received Adriamycin (doxorubicin). All had ophthalmologic, otologic, growth, and cosmetic evaluations; 15 also had dental and maxillofacial examinations. The median age at diagnosis was 6 years (range, 7 months-13 years). Median follow-up from time of diagnosis was 5.5 years with a minimum of 3 years in all but four patients. The major problems encountered were related to the eyes (xerophthalmia and cataracts), ears (hearing loss), teeth (maleruption and caries), glandular structures (xerostomia, hypopituitarism), and development (craniofacial deformity). It is concluded that children treated for soft tissue sarcomas of the head and neck with combined modality therapy, including radiation enhancers, may show a variety of late treatment-related adversities. These children require close multidisciplinary follow-up for detection of late effects in order that appropriate prophylactic or symptomatic treatment can be instituted to minimize their consequences.
Volume
57
Issue
10
First Page
2070
Last Page
2076
ISSN
0008-543X
Published In/Presented At
Fromm, M., Littman, P., Raney, R. B., Nelson, L., Handler, S., Diamond, G., & Stanley, C. (1986). Late effects after treatment of twenty children with soft tissue sarcomas of the head and neck. Experience at a single institution with a review of the literature. Cancer, 57(10), 2070–2076. https://doi.org/10.1002/1097-0142(19860515)57:10<2070::aid-cncr2820571032>3.0.co;2-g
Disciplines
Medicine and Health Sciences | Oncology
PubMedID
3955515
Department(s)
Department of Radiation Oncology
Document Type
Article