The Effect of
Publication/Presentation Date
9-17-2022
Abstract
Diffuse midline gliomas arise in the brainstem and other midline brain structures and cause a large proportion of childhood brain tumor deaths. Radiation therapy is the most effective treatment option, but these tumors ultimately progress. Inhibition of the phosphoinositide-3-kinase (PI3K)-like kinase, ataxia-telangiectasia mutated (ATM), which orchestrates the cellular response to radiation-induced DNA damage, may enhance the efficacy of radiation therapy. Diffuse midline gliomas in the brainstem contain loss-of-function mutations in the tumor suppressor
Volume
14
Issue
18
ISSN
2072-6694
Published In/Presented At
Stewart, C. E., Guerra-García, M. E., Luo, L., Williams, N. T., Ma, Y., Regal, J. A., Ghosh, D., Sansone, P., Oldham, M., Deland, K., Becher, O. J., Kirsch, D. G., & Reitman, Z. J. (2022). The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten-Deleted Brainstem Glioma. Cancers, 14(18), 4506. https://doi.org/10.3390/cancers14184506
Disciplines
Medicine and Health Sciences | Oncology
PubMedID
36139666
Department(s)
Department of Radiation Oncology
Document Type
Article