Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy.

Publication/Presentation Date

9-1-2017

Abstract

OBJECTIVES: Although treatment paradigms have not changed significantly, radiotherapy, surgery, and imaging techniques have improved, leading us to investigate oncologic and survival outcomes for oral cavity squamous cell cancer (OCSCC) patients treated with surgery followed by postoperative IMRT.

MATERIAL AND METHODS: Records of patients with pathological diagnosis of OCSCC treated between 2000 and 2012 were retrospectively reviewed. Patients' demographic, disease, and treatment criteria were extracted. Kaplan-Meier method was used to calculate survival curves.

RESULTS: Two hundred eighty-nine patients were analyzed. Median follow-up was 35months. Two hundred sixty-eight had neck dissections (93%), of which 66% had nodal involvement, and 51% of those positive dissections had extracapsular extension. Forty patients received induction chemotherapy and 107 received concurrent chemotherapy. Median dose to high risk clinical target volume was 60Gy/30 fractions. The 5-year locoregional control and overall survival rates were 76% and 57%, respectively. Tumors with >1.5cm depth of invasion had significantly higher risk of local failure compared with ≤1.5cm (p1.5cm depth of invasion (p=0.003) were independent predictors of poorer survival.

CONCLUSIONS: Disease outcomes were consistent with historical data and did not appear compromised by the use of IMRT.

Volume

72

First Page

90

Last Page

97

ISSN

1879-0593

Disciplines

Medicine and Health Sciences | Oncology

PubMedID

28797467

Department(s)

Department of Radiation Oncology

Document Type

Article

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