Biodistribution and pharmacokinetics of S-35-labeled 5-thio-D-glucose in hamsters bearing pancreatic tumors.
Publication/Presentation Date
7-1-1979
Abstract
5-thio-D-glucose (5-TDG) exerts profound effects on rapidly metabolizing tissues. We have used liquid scintillation counting to study the tissue distribution and pharmacokinetics of S-35-labeled 5-TDG in hamster models of pancreatic tumors. In the normal hamster, initial uptake of S-35 activity into kidney, liver, and blood was high, but rapidly decreased with time. The pancreatic uptake (% dose/g) never exceeded 0.75%. This level occurred only at the earliest times after administration. Uptake in all three tumor models exceeded that in pancreatic tissue within 15 min of injection. The highest tumor-to-pancreas ratio was seen in the duct-tumor model, which also exhibited the most favorable tumor-to-tissue ratio when compared with kidney, liver and muscle. Favorable ratios were most pronounced at 6 and 24 hr after injection. These studies provide impetus for the use of 5-TDG as a model compound for the synthesis of potentially useful agents for clinical detection of pancreatic tumors.
Volume
20
Issue
7
First Page
753
Last Page
760
ISSN
0161-5505
Published In/Presented At
Markoe, A. M., Risch, V. R., Heindel, N. D., Emrich, J., Lippincott, W., Honda, T., & Brady, L. W. (1979). Biodistribution and pharmacokinetics of S-35-labeled 5-thio-D-glucose in hamsters bearing pancreatic tumors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 20(7), 753–760.
Disciplines
Medicine and Health Sciences | Oncology
PubMedID
232149
Department(s)
Department of Radiation Oncology
Document Type
Article