Tentorial venous anatomy of mice and humans.
Publication/Presentation Date
11-8-2021
Abstract
We recently described a transtentorial venous system (TTVS), which to our knowledge was previously unknown, connecting venous drainage throughout the brain in humans. Prior to this finding, it was believed that the embryologic tentorial plexus regresses, resulting in a largely avascular tentorium. Our finding contradicted this understanding and necessitated further investigation into the development of the TTVS. Herein, we sought to investigate mice as a model to study the development of this system. First, using vascular casting and ex vivo micro-CT, we demonstrated that this TTVS is conserved in adult mice. Next, using high-resolution MRI, we identified the primitive tentorial venous plexus in the murine embryo at day 14.5. We also found that, at this embryologic stage, the tentorial plexus drains the choroid plexus. Finally, using vascular casting and micro-CT, we found that the TTVS is the dominant venous drainage in the early postnatal period (P8). Herein, we demonstrated that the TTVS is conserved between mice and humans, and we present a longitudinal study of its development. In addition, our findings establish mice as a translational model for further study of this system and its relationship to intracranial physiology.
Volume
6
Issue
21
ISSN
2379-3708
Published In/Presented At
Lookian, P. P., Chandrashekhar, V., Cappadona, A., Bryant, J. P., Chandrashekhar, V., Tunacao, J. M., Donahue, D. R., Munasinghe, J. P., Smirniotopoulos, J. G., Heiss, J. D., Zhuang, Z., & Rosenblum, J. S. (2021). Tentorial venous anatomy of mice and humans. JCI insight, 6(21), e151222. https://doi.org/10.1172/jci.insight.151222
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
34546977
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article