Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency.
Publication/Presentation Date
1-1-1993
Abstract
We have performed localized in vivo proton magnetic resonance spectroscopy on two females with ornithine carbamoyl transferase deficiency during episodes of acute hyperammonemic encephalopathy with focal neurologic abnormalities. Spectra obtained from 2 x 2 x 2 cm cubic volumes at relatively long (135-ms) echo times contain additional signals that are characteristic of glutamine and indicate that glutamine is present in very high concentrations in the brain. The findings are consistent with the hypothesis that intracerebral accumulation of glutamine contributes to the encephalopathy associated with hyperammonemia. In one of the children, spectra obtained after treatment showed a marked decrease in the glutamine signals.
Volume
33
Issue
1
First Page
77
Last Page
81
ISSN
0031-3998
Published In/Presented At
Connelly, A., Cross, J. H., Gadian, D. G., Hunter, J. V., Kirkham, F. J., & Leonard, J. V. (1993). Magnetic resonance spectroscopy shows increased brain glutamine in ornithine carbamoyl transferase deficiency. Pediatric research, 33(1), 77–81. https://doi.org/10.1203/00006450-199301000-00016
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
8433866
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article