In vivo evidence of brain galactitol accumulation in an infant with galactosemia and encephalopathy.

Authors

G T Berry
J V Hunter
Z Wang
S Dreha
A Mazur
D G Brooks
C Ning
R A Zimmerman
S Segal

Publication/Presentation Date

2-1-2001

Abstract

In a newborn infant with galactose-1-phosphate uridyltransferase deficiency and encephalopathy, brain magnetic resonance imaging revealed cytotoxic edema in white matter. Using in vivo proton magnetic resonance spectroscopy, we detected approximately 8 mmol galactitol per kilogram of brain tissue, an amount potentially relevant to the pathogenesis of brain edema.

Volume

138

Issue

2

First Page

260

Last Page

262

ISSN

0022-3476

Published In/Presented At

Berry, G. T., Hunter, J. V., Wang, Z., Dreha, S., Mazur, A., Brooks, D. G., Ning, C., Zimmerman, R. A., & Segal, S. (2001). In vivo evidence of brain galactitol accumulation in an infant with galactosemia and encephalopathy. The Journal of pediatrics, 138(2), 260–262. https://doi.org/10.1067/mpd.2001.110423

Disciplines

Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology

PubMedID

11174626

Department(s)

Department of Radiology and Diagnostic Medical Imaging

Document Type

Article