Localized 31P magnetic resonance spectroscopy of large pediatric brain tumors.
Publication/Presentation Date
1-1-1990
Abstract
Fourteen children aged 1 week to 16 years, with a variety of large or superficial brain tumors, underwent localized in vivo 31P magnetic resonance spectroscopy of their tumor. Quantitative spectral analysis was performed by measuring the area under individual peaks using a computer algorithm. In eight patients with histologically benign tumors the spectra were considered to be qualitatively indistinguishable from normal brain. The phosphocreatine/inorganic phosphate ratio (PCr/Pi) averaged 2.0. Five patients had histologically malignant tumors; qualitatively, four of these were considered to have abnormal spectra, showing a decrease in the PCr peak. The PCr/Pi ratio for this group averaged 0.85, which was significantly lower than that seen in the benign tumor group (p less than 0.05). No difference between the two groups was seen in adenosine triphosphate or phosphomonoesters. It is concluded that a specific metabolic "fingerprint" for childhood brain tumors may not exist, but that some malignant tumors show a pattern suggestive of ischemia.
Volume
72
Issue
1
First Page
65
Last Page
70
ISSN
0022-3085
Published In/Presented At
Sutton, L. N., Lenkinski, R. E., Cohen, B. H., Packer, R. J., & Zimmerman, R. A. (1990). Localized 31P magnetic resonance spectroscopy of large pediatric brain tumors. Journal of neurosurgery, 72(1), 65–70. https://doi.org/10.3171/jns.1990.72.1.0065
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
2294187
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article