Regional variation in brain lactate in Leigh syndrome by localized 1H magnetic resonance spectroscopy.
Publication/Presentation Date
2-1-1991
Abstract
Localized water-suppressed 1H magnetic resonance spectroscopy was performed in an 11-month-old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalities were seen with routine T2-weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.
Volume
29
Issue
2
First Page
218
Last Page
221
ISSN
0364-5134
Published In/Presented At
Detre, J. A., Wang, Z. Y., Bogdan, A. R., Gusnard, D. A., Bay, C. A., Bingham, P. M., & Zimmerman, R. A. (1991). Regional variation in brain lactate in Leigh syndrome by localized 1H magnetic resonance spectroscopy. Annals of neurology, 29(2), 218–221. https://doi.org/10.1002/ana.410290219
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
2012390
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article