Proton magnetic resonance spectroscopy of pediatric brain tumors.
Publication/Presentation Date
8-1-1992
Abstract
1H magnetic resonance spectroscopy allows the regional quantitation of a number of metabolites from the brain in a noninvasive fashion. Spectra were obtained from 5 normal children and 25 children with brain tumors. Choline (Cho), N-acetylaspartate (NAA), creatine and phosphocreatine, and lactate were quantitated in the form of ratios. The brains of normal children showed relatively high concentrations of Cho and NAA and virtually no lactate, as has been shown in adults. Benign astrocytomas and ependymomas were characterized by an elevation of the Cho:NAA ratio and an abnormal accumulation of lactate. Intrinsic malignant tumors were remarkable for an even higher Cho:NAA ratio but had no more lactate than was found in the benign tumors. Proton magnetic resonance spectroscopy may prove useful in characterizing neoplastic tissue in conjunction with more conventional imaging modalities.
Volume
31
Issue
2
First Page
195
Last Page
202
ISSN
0148-396X
Published In/Presented At
Sutton, L. N., Wang, Z., Gusnard, D., Lange, B., Perilongo, G., Bogdan, A. R., Detre, J. A., Rorke, L., & Zimmerman, R. A. (1992). Proton magnetic resonance spectroscopy of pediatric brain tumors. Neurosurgery, 31(2), 195–202. https://doi.org/10.1227/00006123-199208000-00004
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
1513425
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article