Brainstem gliomas in children. A Children's Cancer Group review of 119 cases.
Publication/Presentation Date
1-1-1996
Abstract
Brainstem gliomas (BSG) with intrinsic and extensive brainstem involvement continue to have a poor outlook despite current treatment approaches. Neuroimaging studies have aided in the differentiation of malignant brainstem tumors from more 'benign' subgroups. A Children's Cancer Group protocol evaluating outcome in children with BSG after treatment with hyperfractionated radiotherapy (7,200-7,800 cGy) was recently completed. The clinical aspects of 119 children entered into this study were reviewed in an attempt to determine risk groups and prognostic indicators. The overall survival of this group was very poor and there was no statistically significant correlation of survival with age, sex, clinical symptoms and signs, or tumor grade. Longer survival was only associated with prolonged duration of brainstem symptoms and signs greater than 1 month prior to diagnosis of the tumor. Improved outlook for children with BSG will require further research in tumor biology and newer therapeutic modalities.
Volume
24
Issue
4
First Page
185
Last Page
192
ISSN
1016-2291
Published In/Presented At
Kaplan, A. M., Albright, A. L., Zimmerman, R. A., Rorke, L. B., Li, H., Boyett, J. M., Finlay, J. L., Wara, W. M., & Packer, R. J. (1996). Brainstem gliomas in children. A Children's Cancer Group review of 119 cases. Pediatric neurosurgery, 24(4), 185–192. https://doi.org/10.1159/000121036
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
8873160
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article