Isolated angiitis of CNS: treatment with pulse cyclophosphamide.
Publication/Presentation Date
1-1-1993
Abstract
A 12-year-old boy with a history of "migraine" headache presented with an increasingly severe headache accompanied by emesis and unsteadiness. Evaluation revealed an acute cerebral hemorrhage with subsequent angiographic studies demonstrating multiple areas of segmental narrowing in both the anterior and posterior cerebral circulations. He was diagnosed with isolated angiitis of the central nervous system and high-dose steroid therapy was administered to which he responded for 6 months. Symptoms recurred and repeat angiography demonstrated persistent segmental narrowing. Pulse cyclophosphamide therapy was begun with resolution of symptoms and normalization of angiography following 6 treatments. Although rare in children, isolated angiitis of the central nervous system can occur in children and aggressive immunosuppression should be considered as the mode of therapy.
Volume
9
Issue
1
First Page
73
Last Page
75
ISSN
0887-8994
Published In/Presented At
Barron, T. F., Ostrov, B. E., Zimmerman, R. A., & Packer, R. J. (1993). Isolated angiitis of CNS: treatment with pulse cyclophosphamide. Pediatric neurology, 9(1), 73–75. https://doi.org/10.1016/0887-8994(93)90017-7
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
8452606
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article