Proton magnetic resonance spectroscopy of brain metabolites in galactosemia.
Publication/Presentation Date
8-1-2001
Abstract
Brain edema may occur in infants with galactosemia and has been associated with accumulation of galactitol. Proton magnetic resonance spectra were obtained from 12 patients (four newly diagnosed neonates and eight patients on galactose-restricted diets, age range 1.7-47 years) and control subjects to measure brain galactitol levels in vivo and correlate them with urinary galactitol excretion. The results demonstrate that a markedly elevated brain galactitol level may be present only in newborn infants with galactosemia who exhibit massive urinary galactitol excretion.
Volume
50
Issue
2
First Page
266
Last Page
269
ISSN
0364-5134
Published In/Presented At
Wang, Z. J., Berry, G. T., Dreha, S. F., Zhao, H., Segal, S., & Zimmerman, R. A. (2001). Proton magnetic resonance spectroscopy of brain metabolites in galactosemia. Annals of neurology, 50(2), 266–269. https://doi.org/10.1002/ana.1102
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
11506413
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article