In vivo brain myo-inositol levels in children with Down syndrome.
Publication/Presentation Date
7-1-1999
Abstract
The Na+/myo-inositol cotransporter (SLC5A3) gene, located on the long arm of human chromosome 21, may play a key role in osmoregulation including the regulation of levels of the "idiogenic osmole," myo-inositol, in brain cells. To determine whether the levels of myo-inositol are increased in the basal ganglia of children with Down syndrome, we performed in vivo brain hydrogen 1-nuclear magnetic resonance or 1H-magnetic resonance spectroscopy and measured plasma osmolality in a cohort of children with trisomy 21. Myo-inositol is elevated in the corpus striatum of infants and children with Down syndrome, even in the absence of hypertonic stress.
Volume
135
Issue
1
First Page
94
Last Page
97
ISSN
0022-3476
Published In/Presented At
Berry, G. T., Wang, Z. J., Dreha, S. F., Finucane, B. M., & Zimmerman, R. A. (1999). In vivo brain myo-inositol levels in children with Down syndrome. The Journal of pediatrics, 135(1), 94–97. https://doi.org/10.1016/s0022-3476(99)70334-3
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
10393611
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article