Association Between Carotid Artery Perivascular Fat Density and Cerebrovascular Ischemic Events.
Publication/Presentation Date
12-18-2018
Abstract
Background Studies have shown that pericoronary artery inflammation can be accurately detected via increased attenuation on computed tomography. Our purpose was to evaluate the association between pericarotid inflammation, measured by density of carotid perivascular fat on computed tomography angiography, with stroke and transient ischemic attack. Methods and Results We screened computed tomography angiography examinations for patients with unilateral internal carotid artery ( ICA ) stenosis ≥50% to 99%. A blinded neuroradiologist placed regions-of-interest in the pericarotid fat on the slice showing maximal stenosis. Two-sample t tests were performed to assess between-subject differences in mean Hounsfield Units in carotid perivascular fat between symptomatic and asymptomatic patients. Paired t tests were used to assess within-subject differences in mean Hounsfield Units between stenotic versus nonstenotic ICA s in a given patient. We included 94 patients, including 42 symptomatic and 52 asymptomatic patients. In the between-subject analysis of stenotic ICA s, we found symptomatic patients had higher mean pericarotid fat density compared with asymptomatic patients (-66.2±19.2 versus -77.1±20.4, P=0.009). When comparing nonstenotic ICA s, there was no significant difference between pericarotid fat density in symptomatic compared with asymptomatic patients (-81.0±13.3 versus -85.3±18.0: P=0.198). Within-subject comparison showed statistically significant increased density in stenotic ICA versus nonstenotic ICA with mean Hounsfield Units difference of 11.1 ( P
Volume
7
Issue
24
First Page
010383
Last Page
010383
ISSN
2047-9980
Published In/Presented At
Baradaran, H., Myneni, P. K., Patel, P., Askin, G., Gialdini, G., Al-Dasuqi, K., Kamel, H., & Gupta, A. (2018). Association Between Carotid Artery Perivascular Fat Density and Cerebrovascular Ischemic Events. Journal of the American Heart Association, 7(24), e010383. https://doi.org/10.1161/JAHA.118.010383
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
30561272
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article