Characterizing Brain Perfusion in a Swine Model of Raised Intracranial Pressure.
Publication/Presentation Date
10-1-2022
Abstract
INTRODUCTION: Perfusion of the brain is critical, but this can be compromised due to focal space occupying lesions (SOL). SOLs can raise intracranial pressure (ICP), resulting in reduced cerebral blood flow (CBF). Most gyrencephalic models of brain injury focus on parenchymal injury, with few models of acutely elevated ICP. We hypothesized that we could employ a SOL technique to develop a titratable ICP model and sought to quantitate the resulting decrease in brain perfusion.
METHODS: Six swine were anesthetized and instrumented. A Fogarty balloon catheter was inserted intracranially. Blood CO
RESULTS: Baseline ICP was 5 ± 2 and systolic blood pressure was 106 ± 7. Balloon volumes (mL) required to achieve each incremental ICP level were 2.4 ± 0.5, 4.9 ± 1.7, 7.6 ± 1.6, and 9.9 ± 1.7. CBF decreased with each raised ICP level, with CBF being significantly less than baseline at ICP values of 30 (56.1 ± 34.7 versus 20.6 ± 11.0, P < 0.05) and 40 (56.1 ± 34.7 versus 6.5 ± 10.6, P < 0.05).
CONCLUSIONS: An intracranial balloon catheter can be used to increase ICP, delivering a proportionate reduction in CBF. This model can be used in the future studies to examine adjuncts that manipulate intracranial pressure and their effect on brain perfusion.
Volume
278
First Page
64
Last Page
69
ISSN
1095-8673
Published In/Presented At
Abdou, H., Edwards, J., Patel, N., Stonko, D. P., Elansary, N., Lang, E., Richmond, M. J., Ptak, T., White, J. M., Scalea, T. M., & Morrison, J. J. (2022). Characterizing Brain Perfusion in a Swine Model of Raised Intracranial Pressure. The Journal of surgical research, 278, 64–69. https://doi.org/10.1016/j.jss.2022.03.034
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
35594616
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article
