"The influence of hemorrhagic shock on brain perfusion in a swine model" by Hossam Abdou, Rebecca Treffalls et al.
 

The influence of hemorrhagic shock on brain perfusion in a swine model of raised intracranial pressure.

Publication/Presentation Date

3-18-2025

Abstract

PURPOSE: In patients with hemorrhagic shock and an intracranial space occupying lesion (SOL), brain perfusion is severely compromised due to raised intracranial pressure (rICP), significantly worsening outcomes. This study aims to develop a swine model of a SOL with rICP and shock and characterize the effect on brain perfusion.

METHODS: Ten male swine were divided into two groups- normal ICP (nICP) and rICP. rICP animals had an intracranial Fogarty balloon catheter inserted, which was infused with saline to simulate a SOL. Animals underwent hemorrhage to systolic blood pressures (SBP) of 60, 40, and 20mmHg. Cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured using CT perfusion.

RESULTS: The CBF/Mean arterial pressure (MAP) and CBV/MAP curves were modeled using non-linear regression, with both groups demonstrating a sigmoid relation. In both the CBF/MAP and CBV/MAP curves, animals with rICP had loss of autoregulation at a higher MAP compared to nICP. The curves were an excellent fit for CBF (nICP R

CONCLUSIONS: This study aids in quantifying the compounding insult of raised ICP and hemorrhage with regard to brain perfusion. Raised ICP results in autoregulatory failure at a higher MAP compared to animals with nICP. These results can help inform future studies that should be aimed at evaluating novel interventions for this complex clinical scenario.

Volume

51

Issue

1

First Page

137

Last Page

137

ISSN

1863-9941

Disciplines

Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology

PubMedID

40102249

Department(s)

Department of Radiology and Diagnostic Medical Imaging

Document Type

Article

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