The complement system of the marsupial Monodelphis domestica.
Publication/Presentation Date
1-1-1998
Abstract
The activation requirements and pathways of the serum C' system of the marsupial Monodelphis domestica were characterized using standard hemolytic procedures. The existence of distinct classical and alternative activation pathways was established on the basis of their ionic requirements, hemolytic capacity at different temperatures, kinetics of hemolysis, and differential susceptibility to the classical pathway inhibitor carrageenan. For the most part, the activities of these pathways were influenced by factors and conditions in a manner similar to the way they affect the activity of eutherian complement. These observations provide further support for the idea that Monodelphis domestica would serve as a useful model for comparative immunological studies in mammals.
Volume
22
Issue
2
First Page
231
Last Page
237
ISSN
0145-305X
Published In/Presented At
Koppenheffer, T. L., Spong, K. D., & Falvo, H. M. (1998). The complement system of the marsupial Monodelphis domestica. Developmental and comparative immunology, 22(2), 231–237. https://doi.org/10.1016/s0145-305x(98)00015-9
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
9639092
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article