Silica sol-gel for the controlled release of antibiotics. I. Synthesis, characterization, and in vitro release.
Publication/Presentation Date
11-1-2001
Abstract
Room temperature processed silica sol-gel (xerogel) was investigated as a novel controlled release carrier of antibiotics (vancomycin). Xerogel characteristics, in vitro release properties, and bactericidal efficacy of the released antibiotic were determined. The xerogel/vancomycin composite showed a long-term sustained release (up to 6 weeks). In addition, bactericidal efficacy of released vancomycin was retained. The kinetics of release and the amount released were dose dependent. The initial, first-order release was followed by a near-zero-order release. The time to transition from the first- to zero-order release increased with vancomycin load (from 2 to 3 weeks with load increase from 2.2 to 11.1 mg/g). Regardless of the load, about 70% of the original vancomycin content was released by the transitional point, and the cumulative release after 6 weeks of immersion was about 90%. This study, combined with other reports documenting biocompatibility and controlled resorbability of the xerogel/drug composite in vivo, suggests that silica xerogel is a promising controlled release material for the treatment of bone infections.
Volume
57
Issue
2
First Page
313
Last Page
320
ISSN
0021-9304
Published In/Presented At
Radin, S., Ducheyne, P., Kamplain, T., & Tan, B. H. (2001). Silica sol-gel for the controlled release of antibiotics. I. Synthesis, characterization, and in vitro release. Journal of biomedical materials research, 57(2), 313–320. https://doi.org/10.1002/1097-4636(200111)57:2<313::aid-jbm1173>3.0.co;2-e
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
11484196
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article