Genome-Wide Analysis in

Authors

Mariann M Gabrawy
Nick Khosravian
George S Morcos, Lehigh Valley Health Network
Tatiana V Morozova
Meagan Jezek
Jeremy D Walston
Wen Huang
Peter M Abadir
Jeff Leips

Publication/Presentation Date

1-14-2022

Abstract

Despite impressive results in restoring physical performance in rodent models, treatment with renin-angiotensin system (RAS) inhibitors, such as Lisinopril, have highly mixed results in humans, likely, in part, due to genetic variation in human populations. To date, the genetic determinants of responses to drugs, such as RAS inhibitors, remain unknown. Given the complexity of the relationship between physical traits and genetic background, genomic studies which predict genotype- and age-specific responses to drug treatments in humans or vertebrate animals are difficult. Here, using 126 genetically distinct lines of

Volume

13

Issue

1

ISSN

2073-4425

Published In/Presented At

Gabrawy, M. M., Khosravian, N., Morcos, G. S., Morozova, T. V., Jezek, M., Walston, J. D., Huang, W., Abadir, P. M., & Leips, J. (2022). Genome-Wide Analysis in Drosophila Reveals the Genetic Basis of Variation in Age-Specific Physical Performance and Response to ACE Inhibition. Genes, 13(1), 143. https://doi.org/10.3390/genes13010143

Disciplines

Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology

PubMedID

35052483

Department(s)

Department of Radiology and Diagnostic Medical Imaging, Fellows and Residents

Document Type

Article