Time-dependent changes in aortic albumin permeability characteristics in experimental diabetes.
Publication/Presentation Date
10-1-1984
Abstract
The aortic albumin flux, mass transport rates, and aortic albumin-plasma ratios were examined at 20, 30, and 60 min following injection of bovine serum albumin conjugated to fluorescein isothiocyanate (FITCBSA) in rats made diabetic via streptozotocin injection (65 mg/kg, jugular vein, ether anesthesia). These studies were undertaken in order to establish some basic semiquantitative permeability parameters of large arteries in experimental diabetes. Data indicate that under diabetic conditions, both the aortic flux and the mass transfer rates are significantly elevated, changes which correspond to increased tissue accumulation of FITCBSA. In addition, the time needed to saturate the albumin space in aortas of diabetic animals is significantly lower than normal.
Volume
41
Issue
2
First Page
207
Last Page
217
ISSN
0014-4800
Published In/Presented At
Hollis, T. M., Enea, N. A., & Kern, J. A. (1984). Time-dependent changes in aortic albumin permeability characteristics in experimental diabetes. Experimental and molecular pathology, 41(2), 207–217. https://doi.org/10.1016/0014-4800(84)90037-6
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
6479292
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article