Assessment of heparin anticoagulation during peripheral angioplasty.
Publication/Presentation Date
2-1-1991
Abstract
The amount of heparin administered during peripheral angioplasty procedures is controversial and varies greatly among angiographers. Complications may result from both excessive and insufficient anticoagulation. The authors characterized the anticoagulant response to heparin in patients undergoing angioplasty by means of the activated clotting time (ACT). The ACT was measured in 64 patients who underwent lower extremity angioplasty. There was a linear relationship between heparin dose and ACT (P = .0001), but the slope of this relationship varied from patient to patient (R2 = .232). The response to heparin was blunted in one patient with thrombosis, but it was not exaggerated in patients with hematomas. Heparin anticoagulant response is highly variable, and heparin administration should be individualized according to ACT to produce a desired level of anticoagulation. Use of the ACT is a convenient and reproducible means of monitoring heparin administration and may increase safety and efficacy during peripheral angioplasty.
Volume
2
Issue
1
First Page
133
Last Page
139
ISSN
1051-0443
Published In/Presented At
Mulry, C. C., Le Veen, R. F., Sobel, M., Lampe, P. J., & Burke, D. R. (1991). Assessment of heparin anticoagulation during peripheral angioplasty. Journal of vascular and interventional radiology : JVIR, 2(1), 133–139. https://doi.org/10.1016/s1051-0443(91)72486-x
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
1839230
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article