Genetic Testing and Screening Recommendations for Patients with Hereditary Breast Cancer.
Publication/Presentation Date
1-1-2020
Abstract
Professionals who specialize in breast imaging may be the first to initiate the conversation about genetic counseling with patients who have a diagnosis of premenopausal breast cancer or a strong family history of breast and ovarian cancer. Commercial genetic testing panels have gained popularity and have become more affordable in recent years. Therefore, it is imperative for radiologists to be able to provide counseling and to identify those patients who should be referred for genetic testing. The authors review the process of genetic counseling and the associated screening recommendations for patients at high and moderate risk. Ultimately, genetic test results enable appropriate patient-specific screening, which allows improvement of overall survival by early detection and timely treatment. The authors discuss pretest counseling, which involves the use of various breast cancer risk assessment tools such as the Gail and Tyrer-Cuzick models. The most common high- and moderate-risk gene mutations associated with breast cancer are also reviewed. In addition to
Volume
40
Issue
4
First Page
913
Last Page
936
ISSN
1527-1323
Published In/Presented At
Bharucha, P. P., Chiu, K. E., François, F. M., Scott, J. L., Khorjekar, G. R., & Tirada, N. P. (2020). Genetic Testing and Screening Recommendations for Patients with Hereditary Breast Cancer. Radiographics : a review publication of the Radiological Society of North America, Inc, 40(4), 913–936. https://doi.org/10.1148/rg.2020190181
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
32469631
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article