In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy.
Publication/Presentation Date
1-24-2023
Abstract
Cancer immunotherapy that deploys the host's immune system to recognize and attack tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted by the immunosuppressive (i.e., immunologically cold) tumor microenvironment (TME). Here, we report an in-situ cryo-immune engineering (ICIE) strategy for turning the TME from immunologically "cold" into "hot". In particular, after the ICIE treatment, the ratio of the CD8
Volume
14
Issue
1
First Page
392
Last Page
392
ISSN
2041-1723
Published In/Presented At
Ou, W., Stewart, S., White, A., Kwizera, E. A., Xu, J., Fang, Y., Shamul, J. G., Xie, C., Nurudeen, S., Tirada, N. P., Lu, X., Tkaczuk, K. H. R., & He, X. (2023). In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy. Nature communications, 14(1), 392. https://doi.org/10.1038/s41467-023-36045-7
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
36693842
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article