In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy.
Cancer immunotherapy that deploys the host's immune system to recognize and attack tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted by the immunosuppressive (i.e., immunologically cold) tumor microenvironment (TME). Here, we report an in-situ cryo-immune engineering (ICIE) strategy for turning the TME from immunologically "cold" into "hot". In particular, after the ICIE treatment, the ratio of the CD8
Published In/Presented At
Ou, W., Stewart, S., White, A., Kwizera, E. A., Xu, J., Fang, Y., Shamul, J. G., Xie, C., Nurudeen, S., Tirada, N. P., Lu, X., Tkaczuk, K. H. R., & He, X. (2023). In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy. Nature communications, 14(1), 392. https://doi.org/10.1038/s41467-023-36045-7
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
Department of Radiology and Diagnostic Medical Imaging