Hypoxic-ischemic encephalopathy in areas of primary myelination: a neuroimaging and PET study.
Publication/Presentation Date
2-1-1996
Abstract
The stage of regional structural and biochemical development of the central nervous system appears as a critical factor determining the distribution of hypoxic-ischemic lesions during the perinatal period. We describe the brain lesions in 12 patients who suffered hypoxia-ischemia during the perinatal period. The gestational age ranged from 35 to 42 weeks and the age at death from 2 to 16 weeks. There is one patient alive at age 18 years and a second patient at age 1 year. The cerebral cortical damage is mainly restricted to areas of primary myelination and adjacent subcortical white matter. In addition, there is thalamic, basal ganglia, brainstem, and spinal cord damage. It is postulated that selective damage occurs in those areas which at the moment of the hypoxic-ischemic insult had achieved higher rates of oxygen-glucose utilization. This hypothesis is supported by studies utilizing positron emission tomography which indicates that glucose utilization in the normal human neonatal brain follows a phylogenetic order. Regions that achieved higher levels of glucose consumption are those that suffered the brunt of the damage in our term neonates.
Volume
14
Issue
2
First Page
108
Last Page
116
ISSN
0887-8994
Published In/Presented At
Azzarelli, B., Caldemeyer, K. S., Phillips, J. P., & DeMyer, W. E. (1996). Hypoxic-ischemic encephalopathy in areas of primary myelination: a neuroimaging and PET study. Pediatric neurology, 14(2), 108–116. https://doi.org/10.1016/0887-8994(96)00010-0
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
8703222
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article