Alterations in biological properties of different lines of cytomegalorivus-transformed human embryo lung cells following in vitro cultivation.
Publication/Presentation Date
1-1-1978
Abstract
Diverse alterations in biological properties of CMV-transformed cell lines were observed during prolonged in vitro cultivation. In the CMV-Mj-HEL-2 parent line there was a gradual decrease in the number of cells expressing CMV-related antigens; at the same time, an increase in oncogenicity was observed. One tumour line, designated CMV-Mj-HEL-2,T-1, however, retained the original ratio of cells expressing CMV-related antigens for over 100 in vitro passages. The cells lost their original moderate oncogenicity during this period. A later increase in the ratio of cells without CMV antigenic markers was accompanied by the return of moderate tumorigenicity and karyotypic changes. Both cell lines were studied to determine sensitivity to superinfection with herpesviruses, induction of immune response in nude mice, and release of infectious virus.
Issue
24 Pt 2
First Page
591
Last Page
601
Published In/Presented At
Geder, L., Laychock, A. M., Gorodecki, J., & Rapp, F. (1978). Alterations in biological properties of different lines of cytomegalorivus-transformed human embryo lung cells following in vitro cultivation. IARC scientific publications, (24 Pt 2), 591–601.
Disciplines
Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology
PubMedID
221382
Department(s)
Department of Radiology and Diagnostic Medical Imaging
Document Type
Article