Breast Cancer Genomics: Primary and Most Common Metastases.

Authors

Caroline Bennett
Caleb Carroll
Cooper Wright
Barbara Awad
Jeong Mi Park
Meagan Farmer
Elizabeth Bryce Brown
Alexis Heatherly
Stefanie Woodard

Publication/Presentation Date

6-21-2022

Abstract

Specific genomic alterations have been found in primary breast cancer involving driver mutations that result in tumorigenesis. Metastatic breast cancer, which is uncommon at the time of disease onset, variably impacts patients throughout the course of their disease. Both the molecular profiles and diverse genomic pathways vary in the development and progression of metastatic breast cancer. From the most common metastatic site (bone), to the rare sites such as orbital, gynecologic, or pancreatic metastases, different levels of gene expression indicate the potential involvement of numerous genes in the development and spread of breast cancer. Knowledge of these alterations can, not only help predict future disease, but also lead to advancement in breast cancer treatments. This review discusses the somatic landscape of breast primary and metastatic tumors.

Volume

14

Issue

13

ISSN

2072-6694

Published In/Presented At

Bennett, C., Carroll, C., Wright, C., Awad, B., Park, J. M., Farmer, M., Brown, E. B., Heatherly, A., & Woodard, S. (2022). Breast Cancer Genomics: Primary and Most Common Metastases. Cancers, 14(13), 3046. https://doi.org/10.3390/cancers14133046

Disciplines

Diagnosis | Medicine and Health Sciences | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiology

PubMedID

35804819

Department(s)

Department of Radiology and Diagnostic Medical Imaging

Document Type

Article