Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review.

Authors

Molly Monsour
Jonah Gordon
Gavin Lockard, Lehigh Valley Health NetworkFollow
Cesar V Borlongan

Publication/Presentation Date

1-1-2023

Abstract

The immense neuroinflammation induced by multiple sclerosis (MS) promotes a favorable environment for ischemic stroke (IS) development, making IS a deadly complication of MS. The overlapping inflammation in MS and IS is a prelude to the vascular pathology, and an inherent cell death mechanism that exacerbates neurovascular unit (NVU) impairment in the disease progression. Despite this consequence, no therapies focus on reducing IS incidence in patients with MS. To this end, the preclinical and clinical evidence we review here argues for cell-based regenerative medicine that will augment the NVU dysfunction and inflammation to ameliorate IS risk.

Volume

32

First Page

9636897231184596

Last Page

9636897231184596

ISSN

1555-3892

Published In/Presented At

Monsour, M., Gordon, J., Lockard, G., & Borlongan, C. V. (2023). Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review. Cell transplantation, 32, 9636897231184596. https://doi.org/10.1177/09636897231184596

Disciplines

Education | Medical Education | Medicine and Health Sciences

PubMedID

37515536

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article