USF-LVHN SELECT
The role of miRNA in inflammation and autoimmunity.
Publication/Presentation Date
10-1-2013
Abstract
miRNAs are small non-coding RNA molecules that modulate the expression of multiple protein-encoding genes at the post-transcriptional level. They have recently been recognized as powerful regulators of numerous genes and pathways in the pathogenesis of inflammatory and autoimmune diseases. The targets of most miRNAs remain unknown and their roles in biological processes such as cell differentiation, proliferation, and death (apoptosis) are not clearly understood. In this review we will discuss how certain candidate miRNAs affect inflammatory and immune mediated diseases by regulating their cellular and molecular targets. We focused the influence of gender and sex hormones on miRNA. We believe that understanding the role of miRNAs could shed light on the cause and progression of many inflammatory and autoimmune diseases and eventually lay the groundwork for therapeutic options.
Volume
12
Issue
12
First Page
1160
Last Page
1165
ISSN
1873-0183
Published In/Presented At
Singh, R. P., Massachi, I., Manickavel, S., Singh, S., Rao, N. P., Hasan, S., Mc Curdy, D. K., Sharma, S., Wong, D., Hahn, B. H., & Rehimi, H. (2013). The role of miRNA in inflammation and autoimmunity. Autoimmunity reviews, 12(12), 1160–1165. https://doi.org/10.1016/j.autrev.2013.07.003
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
23860189
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article