Intravascular large B-cell lymphoma masquerading as stroke successfully treated with R-Hyper-CVAD.

Authors

Christopher Popiolek, Lehigh Valley Health NetworkFollow
Kanchan Gupta
Mallorie L. Huff, Lehigh Valley Health NetworkFollow
Ranju Gupta MD, Lehigh Valley Health NetworkFollow

Publication/Presentation Date

1-1-2024

Abstract

Intravascular large B cell lymphoma (IVLBCL) is exceedingly rare and difficult to diagnose. We describe a case of IVLBCL in a 56-year-old male which was identified after recurrent strokes. Right partial nephrectomy was then performed which demonstrated renal oncocytoma and IVLBCL. Chemotherapy was initiated with standard R-Hyper-CVAD which included intrathecal methotrexate and cytarabine. R-CHOP is largely considered the treatment of choice in IVLBCL, however low doses of chemotherapy in this regimen do not cross the blood brain barrier like in R-Hyper-CVAD. The patient achieved complete remission after completion of treatment and has remained in remission for 5 years after diagnosis.

Volume

21

First Page

100401

Last Page

100401

ISSN

2213-0489

Published In/Presented At

Popiolek, C., Gupta, K., Huff, M. L., & Gupta, R. (2023). Intravascular large B-cell lymphoma masquerading as stroke successfully treated with R-Hyper-CVAD. Leukemia research reports, 21, 100401. https://doi.org/10.1016/j.lrr.2023.100401

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

38124760

Department(s)

Department of Medicine, Hematology-Medical Oncology Division, USF-LVHN SELECT Program, USF-LVHN SELECT Program Faculty, USF-LVHN SELECT Program Students

Document Type

Article