B-cell ALL with SOX11 gene amplification associates with a worse outcome.

Authors

George Angelakakis, Lehigh Valley Health NetworkFollow
Mallika Varkhedi
Toriana R Dabkowski, Lehigh Valley Health NetworkFollow
Michael J Diaz
Michelle Yeagley
George Blanck

Publication/Presentation Date

2-13-2024

Abstract

Copy number variation (CNV) of certain genes in pediatric Acute Lymphoblastic Leukemia (ALL) impacts gene expression levels. Here, we aimed to investigate the potential prognostic utility of CNVs in pediatric B-ALL and T-ALL. Using genomics files representing cases from the TARGET-ALL-P2 dataset, genes commonly involved in ALL development were analyzed for CNVs. Case IDs representing increased copy numbers for

First Page

1

Last Page

7

ISSN

1551-4005

Published In/Presented At

Angelakakis, G., Varkhedi, M., Dabkowski, T. R., Diaz, M. J., Yeagley, M., & Blanck, G. (2024). B-cell ALL with SOX11 gene amplification associates with a worse outcome. Cell cycle (Georgetown, Tex.), 1–7. Advance online publication. https://doi.org/10.1080/15384101.2024.2306756

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

38350028

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article