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USF-LVHN SELECT
The Gastrointestinal Microbiome and Immune Checkpoint Inhibitors: A Review of Human Interventional Studies Among Melanoma Patients.
Publication/Presentation Date
2-1-2024
Abstract
Immune checkpoint inhibitors (ICI) are widely utilized for the treatment of malignant melanoma. Interestingly, gastrointestinal microbiome composition has emerged as a predictive biomarker of immunotherapy outcomes. This review seeks to assess the effect of microbiota-modulatory interventions on the clinical and immunological response of metastatic melanoma treated with ICIs. A systematic search was performed to retrieve studies and cases involving any microbiota-modulating intervention. Three studies assessed the effect of fecal microbiota transplantation (FMT) on ICI efficacy, and one case report assessed its effect on clearance of ICI-associated colitis. Overall, 37.5% of melanoma patients who had been previously refractory to ICI immunotherapy demonstrated complete or partial response following FMT and subsequent immunotherapy. 65% of immunotherapy-naïve melanoma patients demonstrated an objective response. No severe FMT-associated adverse events were reported, and FMT depicted efficacy in the remission of ICI-associated colitis. The results suggest that FMT may be a safe and moderately effective microbiota-modulating intervention to improve the efficacy of therapy in ICI-treated melanoma patients. Large, randomized, controlled trials are needed to determine optimal FMT donors and assess other microbiota-modulating interventions, such as pre- and probiotics, in melanoma patients. J Drugs Dermatol. 2024;23(2):78-84. doi:10.36849/JDD.7674.
Volume
23
Issue
2
First Page
78
Last Page
84
ISSN
1545-9616
Published In/Presented At
Natarelli, N., Aflatooni, S., Boby, A., Krenitsky, A., & Grichnik, J. (2024). The Gastrointestinal Microbiome and Immune Checkpoint Inhibitors: A Review of Human Interventional Studies Among Melanoma Patients. Journal of drugs in dermatology : JDD, 23(2), 78–84. https://doi.org/10.36849/JDD.7674
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
38306142
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article