Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature.

Authors

Nicole Natarelli, Lehigh Valley Health NetworkFollow
Nimrit Gahoonia
Shaliz Aflatooni, Lehigh Valley Health NetworkFollow
Sahibjot Bhatia
Raja K Sivamani

Publication/Presentation Date

3-14-2024

Abstract

Mitochondria are eukaryotic cellular organelles that function in energy metabolism, ROS production, and programmed cell death. Cutaneous epithelial and hair follicle dermal papilla cells are energy-rich cells that thereby may be affected by mitochondrial dysfunction and DNA mutation accumulation. In this review, we aimed to summarize the medical literature assessing dermatologic conditions and outcomes associated with mitochondrial dysfunction. A search of PubMed and Embase was performed with subsequent handsearching to retrieve additional relevant articles. Mitochondrial DNA (

Volume

25

Issue

6

ISSN

1422-0067

Published In/Presented At

Natarelli, N., Gahoonia, N., Aflatooni, S., Bhatia, S., & Sivamani, R. K. (2024). Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature. International journal of molecular sciences, 25(6), 3303. https://doi.org/10.3390/ijms25063303

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

38542277

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article