USF-LVHN SELECT
ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome.
Publication/Presentation Date
1-1-2023
Abstract
Paraneoplastic Cushing's syndrome arises when neuroendocrine tumors cause excess glucocorticoid production. We report a case of ectopic ACTH-producing liver neuroendocrine tumor. A 71 y.o. female with a history of rectal squamous carcinoma presented with fatigue and diffuse swelling. Liver biopsy revealed metastatic neuroendocrine carcinoma. Workup revealed markedly elevated morning cortisol and ACTH. Overnight dexamethasone suppression testing and positive immunostaining for ACTH on biopsy suggested paraneoplastic Cushing's syndrome secondary to neuroendocrine hepatic tumors with bony metastasis. This explained the patient's persistent anasarca, hyperglycemia, and electrolyte abnormalities. Despite multiple interventions, the patient's clinical status declined, and she expired.
Volume
2023
First Page
9946271
Last Page
9946271
ISSN
2090-6706
Published In/Presented At
Sandozi, M., Pamulapati, S., Zaidi, A., Stuart, Z., Pamulapati, S., & Doniparthi, A. (2023). ACTH-Producing Neuroendocrine Carcinoma of the Liver with Cushing's Syndrome. Case reports in oncological medicine, 2023, 9946271. https://doi.org/10.1155/2023/9946271
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
37794851
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article