USF-LVHN SELECT
Hidradenitis Suppurativa: Molecular Etiology, Pathophysiology, and Management-A Systematic Review.
Publication/Presentation Date
5-17-2023
Abstract
Hidradenitis suppurativa is a chronic inflammatory skin condition that affects the hair follicles in areas of the body with apocrine glands. The condition is characterized by recurrent, painful nodules, abscesses, and draining sinuses that can lead to scarring and disfigurement. In this present study, we provide a focused evaluation of recent developments in hidradenitis suppurativa research, including novel therapeutics and promising biomarkers that may facilitate clinical diagnosis and treatment. We conducted a systematic review of controlled trials, randomized controlled trials, meta-analyses, case reports, and Cochrane Review articles in accordance with the PRISMA guidelines. The Cochrane Library, PubMed, EMBASE, and Epistemonikos databases were queried via Title/Abstract screen. Eligibility criteria included the following: (1) has a primary focus on hidradenitis suppurativa, (2) includes measurable outcomes data with robust comparators, (3) details the sample population, (4) English language, and (5) archived as full-text journal articles. A total of 42 eligible articles were selected for review. Qualitative evaluation identified numerous developments in our understanding of the disease's multiple potential etiologies, pathophysiology, and treatment options. It is important for individuals with hidradenitis suppurativa to work closely with a healthcare provider to develop a comprehensive treatment plan that addresses their individual needs and goals. To meet this objective, providers must keep current with developments in the genetic, immunological, microbiological, and environmental factors contributing to the disease's development and progression.
Volume
45
Issue
5
First Page
4400
Last Page
4415
ISSN
1467-3045
Published In/Presented At
Diaz, M. J., Aflatooni, S., Abdi, P., Li, R., Anthony, M. R., Neelam, S., Farkouh, C., Tran, J. T., Svoboda, S., Forouzandeh, M., & Valdes Rodriguez, R. H. (2023). Hidradenitis Suppurativa: Molecular Etiology, Pathophysiology, and Management-A Systematic Review. Current issues in molecular biology, 45(5), 4400–4415. https://doi.org/10.3390/cimb45050280
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
37232749
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article