USF-LVHN SELECT
TCR CDR3-CMV Antigen Chemical Complementaries Are Associated With a Worse Outcome for Renal Cell Carcinoma.
Publication/Presentation Date
4-1-2024
Abstract
BACKGROUND/AIM: Due to still unresolved questions regarding viruses as either a primary cause or a comorbidity in cancer, we examined a potential immune response to cytomegalovirus (CMV) in the renal cell carcinoma (RCC) setting using genomics and bioinformatics approaches.
MATERIALS AND METHODS: Specifically, we assessed chemical complementarity scores (CSs) for solid tissue normal resident, T-cell receptor (TCR) complementarity determining region 3 (CDR3s) and CMV antigens and determined whether higher or lower CS groups were associated with a higher or lower survival probability.
RESULTS: This was indeed the case, with all such analyses consistently indicating a lower overall and progression-free survival for the cases representing the higher TCR CDR3-CMV antigen chemical CSs. This basic result was obtained for two separate RCC datasets and multiple CMV antigens.
CONCLUSION: The results raise the question, to what extent a systemic CMV infection may represent an important co-morbidity for RCC.
Volume
44
Issue
4
First Page
1505
Last Page
1511
ISSN
1791-7530
Published In/Presented At
Alkassab, L., Diaz, M. J., Fetcher, E. A., Huda, T. I., Paul, S., Kumar, S., Chobrutskiy, A., Chobrutskiy, B. I., Song, J. J., & Blanck, G. (2024). TCR CDR3-CMV Antigen Chemical Complementaries Are Associated With a Worse Outcome for Renal Cell Carcinoma. Anticancer research, 44(4), 1505–1511. https://doi.org/10.21873/anticanres.16947
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
38537966
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article