USF-LVHN SELECT
Decoding functional hematopoietic progenitor cells in the adult human lung.
Publication/Presentation Date
2-16-2024
Abstract
The bone marrow is the main site of blood cell production in adults, however, rare pools of hematopoietic stem and progenitor cells with self-renewal and differentiation potential have been found in extramedullary organs. The lung is primarily known for its role in gas exchange but has recently been described as a site of blood production in mice. Here, we show that functional hematopoietic precursors reside in the extravascular spaces of the human lung, at a frequency similar to the bone marrow, and are capable of proliferation and engraftment. The organ-specific gene signature of pulmonary and medullary CD34
Published In/Presented At
Conrad, C., Magnen, M., Tsui, J., Wismer, H., Naser, M., Venkataramani, U., Samad, B., Cleary, S. J., Qiu, L., Tian, J. J., De Giovanni, M., Mende, N., Passegue, E., Laurenti, E., Combes, A. J., & Looney, M. R. (2024). Decoding functional hematopoietic progenitor cells in the adult human lung. Research square, rs.3.rs-3576483. https://doi.org/10.21203/rs.3.rs-3576483/v1
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
38077002
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article