USF-LVHN SELECT
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
Publication/Presentation Date
10-1-2021
Abstract
BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have been suggested as potential genetic host factors that affect individual immune response to SARS-CoV-2. We sought to evaluate this hypothesis by conducting a multicenter study using HLA sequencing.
METHODS: We analyzed the association between COVID-19 severity and HLAs in 435 individuals from Germany (
FINDINGS: We describe a potential association of HLA-C*04:01 with severe clinical course of COVID-19. Carriers of HLA-C*04:01 had twice the risk of intubation when infected with SARS-CoV-2 (risk ratio 1.5 [95% CI 1.1-2.1], odds ratio 3.5 [95% CI 1.9-6.6], adjusted
INTERPRETATION: HLA-C*04:01 carrier state is associated with severe clinical course in SARS-CoV-2. Our findings suggest that HLA class I alleles have a relevant role in immune defense against SARS-CoV-2.
FUNDING: Funded by Roche Sequencing Solutions, Inc.
Volume
40
First Page
101099
Last Page
101099
ISSN
2589-5370
Published In/Presented At
Weiner, J., Suwalski, P., Holtgrewe, M., Rakitko, A., Thibeault, C., Müller, M., Patriki, D., Quedenau, C., Krüger, U., Ilinsky, V., Popov, I., Balnis, J., Jaitovich, A., Helbig, E. T., Lippert, L. J., Stubbemann, P., Real, L. M., Macías, J., Pineda, J. A., Fernandez-Fuertes, M., … Heidecker, B. (2021). Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01. EClinicalMedicine, 40, 101099. https://doi.org/10.1016/j.eclinm.2021.101099
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
34490415
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article