USF-LVHN SELECT
Management of Bone Disease with Concurrent Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma.
Publication/Presentation Date
6-26-2024
Abstract
In the intricate landscape of multiple myeloma, a hematologic malignancy of plasma cells, bone disease presents a pivotal and often debilitating complication. The emergence of Chimeric Antigen Receptor T-cell (CAR-T) therapy has marked a pivotal shift in the therapeutic landscape, offering novel avenues for the management of MM, particularly for those with relapsed or refractory disease. This innovative treatment modality not only targets malignant cells with precision but also influences the bone microenvironment, presenting both challenges and opportunities in patient care. In this comprehensive review, we aim to examine the multifaceted aspects of bone disease in patients with multiple myeloma and concurrent CAR-T therapy, highlighting its clinical ramifications and the latest advancements in diagnostic modalities and therapeutic interventions. The article aims to synthesize current understanding of the interplay between myeloma cells, CAR-T cells, and the bone microenvironment in the context of current treatment strategies in this challenging and unique patient population.
First Page
104429
Last Page
104429
ISSN
1879-0461
Published In/Presented At
Kuruvilla, D., Huynh, T., Nester, M., Chose, C., Zervoudakis, G., Letson, G. D., Joyce, D. M., Binitie, O. T., Figura, N. B., Costello, J. R., Freeman, C. L., & Lazarides, A. L. (2024). Management of Bone Disease with Concurrent Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma. Critical reviews in oncology/hematology, 104429. Advance online publication. https://doi.org/10.1016/j.critrevonc.2024.104429
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
38942219
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article